I'm currently on Pop! OS 22.04 LTS. For me it worked out of the box. That installer with the NVidia drivers already included was a dream, so I didn't have to set up anything special. I did end up preferring the KDE desktop over Gnome, so I just went screw it and installed KDE plasma on top of it. It's been my daily driver like this for years.
Though, honesty requires me to mention that over the 4-ish years I've been using it they pushed a kernel update twice which killed the nvidia drivers, causing you to be unable to boot to the desktop. Solution was as simple as just rebooting into the previous kernel for a while and waiting for an update which fixes it, but still...
Other than that, pretty happy with it and I'm unlikely to change anytime soon.