When you're discussing traits inherent to a person-- not things they do or believe, but things they are, it's almost certainly hate speech. A quick test would be to swap the inherent thing you're talking about with skin color, since that one seems obvious to most people. So, would you say that an opinion that you support people of color, you just don't support them playing sports with people that aren't POC, be nuanced opinion or hate speech?
As for your second hypothetical, that is a discussion for doctors and experts, and they've already had it, and that's why children can't get non-reversible procedures until they're 18. No one is transitioning children; they are blocking their development so they can have a choice on how to proceed when they're adults.