madalinai

madalinai, 7 months ago to science

Some research papers conclude that stevia consumption can cause cancer due to DNA breakage and chromosome mutations. However, none of those studies are based on human subjects.
According to a study published in Oncotarget in 2018, steviol significantly limited the growth of human gastrointestinal cancer cells.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://www.bekarmic.com/blogs/knowledge-base/stevia-and-cancer-everything-about-stevia

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madalinai, 7 months ago to science

The use of steviol glycosides as non-caloric sweeteners has proven to be beneficial for patients with type 2 diabetes mellitus (T2D), obesity, and metabolic syndrome. However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism. Herein, we evaluated the impact of steviol, steviol glycosides, and a Greek-derived stevia extract on a number of key steps of GR signaling cascade in peripheral blood mononuclear cells (PBMCs) and in Jurkat leukemia cells. #Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/28754349/

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madalinai, 7 months ago to science

Prostate cancer is the second most harmful disease in men worldwide and the number of cases is increasing. Therefore, new natural agents with anticancer potential should be examined and the response of existing therapeutic drugs must be enhanced. Stevia pilosa and Stevia eupatoria are two species that have been widely used in traditional medicine, but their effectiveness on cancer cells and their interaction with antineoplastic drugs have not been studied. The results indicate that SPME and SEME have an inhibitory effect on the viability and migration of prostate cancer cells and do not interfere with the enzalutamide anticancer effect. The data suggest that Stevia extracts may be a potential source of molecules for cancer treatment.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/32102219/

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madalinai, 7 months ago to science

Steviol glycosides are currently being used as natural sweeteners by the food industry and Stevia rebaudiana has long been used as a sweet plant in South America for patients suffering from diabetes. In this study, a Stevia rebaudiana ethanolic extract (SREE) was prepared, analysed and tested for antioxidant activity in terms of free radical scavenging properties and antiproliferative effects in cervix (HeLa), pancreatic (MiaPaCa-2) and colonic (HCT116) cancer cells. The antiproliferative mechanism was confirmed by testing the effects on cyclin D1-CDK4. #Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/27071804/

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madalinai, 7 months ago to science

Hydroponics offers a viable solution for obtaining plant products that are rich in micronutrients and ultramicronutrients, such as selenium. Selenium plays a crucial role in strengthening the body's immune defense and acts as a potent antioxidant. Low levels of selenium have been associated with an increased risk of heart attacks, strokes, and cancer. Stevia rebaudiana Bertoni (SrB), a relatively new crop in plant cultivation, was the focus of the present study. SrB has numerous medicinal and prophylactic properties, and its leaves are rich in macro- and microelements, vitamins, and diterpene glycosides.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/37522778/

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madalinai, 7 months ago to science

Stevia is unaffected by stomach acid, pancreatic enzymes and the process of digestion. It travels essentially “untouched” by the digestive process until it reaches the large intestine. There it “reacts” with the gut flora. It is then absorbed in the colon and travels to the liver. It is then bound to glucuronic acid via the glucuronidation pathway and eventually excreted through the urine. The glucuronidation pathway is a major liver pathway that detoxifies drugs, pollutants, estrogen, and steroids, etc.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://www.portalsalud.com/cuales-son-los-peligros-de-la-stevia_13092860/

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madalinai, 7 months ago to science

Bladder cancer (BC) is a global health issue that lacks effective treatment strategies. Growing evidence suggests that various natural products possess anti-tumour effects. This study aims to identify a novel agent that can be used in the treatment of BC.
Collectively, our data suggest that stevioside can be a potential agent for the treatment of BC.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/35820501/

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madalinai, 7 months ago to science

More than 60 naturally occurring steviol glycosides in the Stevia rebaudiana Bertoni plant share a similar molecular structure with an aglycone steviol backbone conjugated with β- and α-glycosidic bonds to different sugar moieties. These glycosides are naturally produced in different quantities within the stevia leaf. Certain minor glycosides with superior sensory attributes, such as Reb D and Reb M, are found less than 0.1% in traditional stevia leaves. New technologies can now produce better tasting steviol glycosides by using enzymatic conversion of stevioside and Reb A, which are abundant in stevia leaf. Several regulatory authorities recently evaluated steviol glycosides produced by enzymatic conversion of stevia leaf extract and approved them safe for human consumption. Steviol glycosides undergo microbial hydrolysis in the colon to generate steviol, which is absorbed and metabolized into steviol glucuronide, and excreted primarily via human's urine. Previous studies have shown the hydrolysis of highly purified individual steviol glycosides extracted from stevia leaf are converted to steviol in the presence of colonic microbiota of adults. Since colonic microbiota of children may be different from adults, this study investigates the metabolic fate in the colonic microbiota of adults and children of the minor steviol glycosides produced by extraction and enzymatic conversion of major steviol glycosides from stevia leaf. Several in vitro incubation tests were conducted in human fecal homogenates collected from adult and pediatric populations with steviol glycoside test samples comprised of a complex stevia leaf extract, a blend of minor glycosides isolated from stevia extract and two mixtures of steviol glycosides produced by enzymatic conversion of Reb A to larger molecules by attaching glucose units via β- or α-glycosidic bonds. Results from these studies clearly demonstrate steviol glycosides produced by extraction from stevia leaf, or enzymatic conversion of stevia leaf extract, share the same metabolic fate in the human gut microbiota from adults and children. Considering a common metabolite structure and a shared metabolic fate in all ages, safety data for individual steviol glycosides can be used to support safety of all steviol glycosides produced by extraction and enzymatic conversion of stevia leaf extract.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/32745585/

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madalinai, 7 months ago to science

Stevia rebaudiana Bertoni is a valuable plant whose products are increasingly used in medicine, pharmacy and the food industry. This necessitates the use of biotechnological approaches for its mass propagation. Establishing optimal conditions for in vitro cultivation is essential for obtaining high biomass and secondary metabolites production. A large number of articles considering the role of plant growth regulators and other additives in the culture medium in the growth and development of Stevia are available in the literature. However, there are no summarized data about the use of nanoparticles in Stevia tissue cultures. Therefore, this review also includes the research conducted so far on the effect of nanoparticles on Stevia micropropagation. Furthermore, the influence of different elicitors on secondary metabolite production and antioxidant activity of in vitro-cultivated Stevia plants have been discussed. By referring to the collected literature, we concluded that biotechnological approaches applied to S. rebaudiana cultivation might improve the agronomic traits of plants and steviol glycosides production.
#Stevia #kombucha #ikombucha_ro #ikombucha
https://pubmed.ncbi.nlm.nih.gov/36616282/

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